Evaluation of Depth of Invasion in Oral Squamous Cell Carcinoma with Ultra-High Frequency Ultrasound: A Preliminary Study

Intraoral ultrasonography has been widely employed for the preoperative assessment of tumor margins due to its capability evaluate depth invasion (DOI) and thickness (TT). Recently, a novel ultrasonographic technique, ultra-high frequency ultrasound (UHFUS) increasingly applied study oral lesions. This evaluates potential application intraoral UHFUS assess DOI TT parameters squamous cell carcinoma (OSCC) Patients clinically suspected OSCC lesions were enrolled underwent an examination preoperatively. The TT, DOI, echogenicity, vascularization assessed. as evaluated by means compared histology, which was set benchmark. Ten patients in total enrolled. UHFUS-based measurements found positively correlate with histology (p < 0.05), although provided slight overestimation DOI. No differences terms echogenicity or depending on site lesion. According these preliminary results, could support potentially enhancing clinical evaluation OSCC.